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 Program
We are pleased to say that the 6th Cachexia Conference held in Milan, December 2011 was an outstanding success.
An excerpt about the conference from the newspaper, 'La Stampa', as published on the December 15, 2011 is available. This article appeared in the 'Medicine' section.
Please note that the conference was granted 15 European CME credits (ECMEC) by the EACCME (European Accreditation Council for Continuing Medical Education).
Over 160 abstracts were received. Some abstracts will be published in the March issue - No. 1/2012 - of the Journal of Cachexia, Sarcopenia and Muscle (JCSM).
Thankyou for your ongoing support.
The Society
on Sarcopenia, Cachexia
and Wasting Disorders (SCWD)
Day 1 Thursday, 8 December 2011
A 13:30 - 15:30 - OPENING SESSION (Plenary room) Chairs:
Giuseppe Rosano, Rome, Italy
Filippo Rossi-Fanelli, Rome, Italy
Akio Inui, Kagoshima, Japan
WELCOME: Stefan Anker, Berlin, Germany
“Prometheus” basic science key note lecture: Cachexia as an energy wasting syndrome Josep Argiles, Barcelona, Spain
Ghrelin – Important hormone and treatment option for cachexia Florian Strasser, St Gallen, Switzerland
Accelerated loss of muscle in elderly people with inactivity William Evans, Research Triangle Park, USA
Influence of muscle wasting on outcomes in the Western World Vickie Baracos, Edmonton, Canada
Influence of muscle wasting on outcomes in Japan Koichi Takayama, Fukuoka, Japan
15:30 - 16:00 - Coffee break
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6th Cachexia Conference
8-10 Dec. 2011
ATAHotel Executive
(View website)
Viale Don Luigi Sturzo,
45 - 20154 Milan
[Directly in front of Porta Garibaldi Railway Station]
Milan, Italy
Contact:
Society on Sarcopenia, Cachexia and Wasting Disorders (SCWD)
C/O MedEd Global Solutions
75, rue Guy Môquet
92240 Malakoff
France
Phone: (+33) 1 42 53 03 03
Fax: (+33) 1 42 53 03 02
Email: SCWD@mededgs.com
Accreditation
6th Cachexia Conference is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. The EACCME is an institution of the European union of Medical Specialists (uEMS), www.uems.net.
The 6th Cachexia Conference is designated for a maximum of 15 hours of European external CME credits. Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. |
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B 16:00 - 17:45 - PLENARY SESSION (Plenary room) Chairs:
William Evans, Research Triangle Park, USA
Ken Fearon, Edinburgh, UK
“Hippocrates” clinical science key note lecture: Sarcopenia vs. osteopenia/osteroporosis Steven Cummings, San Francisco, USA
Update from Trialist Workshop 2010: cancer cachexia Stefan Anker, Berlin, Germany
Update from Trialist Workshop 2010: sarcopenia definition John Morley, St Louis, USA
How to measure undernutrition Bruno Vellas, Toulouse, France
From sarcopenia to frailty Tamara Harris, Bethesda, USA
18:00 - 19:15 - Welcome reception and poster viewing (Poster area)
Day 2 Friday, 9 December 2011
07:15 - 08:15 - BREAKFAST SYMPOSIUM - Friday 9th December Cristallo Room - Breakfast served from 06:50 am
Oncology Supportive Care Breakfast Symposium
The cachexia, nausea and vomiting linkage throughout the cancer continuum
Chair: Stefan D. Anker, MD PhD Professor of Cardiology & Cachexia Research Applied Cachexia Research, Dept of Cardiology Charité, Campus Virchow-Klinikum, Berlin, Germany
Speaker: Harry Raftopoulos, MD Associate Professor of Medicine Hofstra North Shore-LIJ School of Medicine, New York, USA Supported by Helsinn View full breakfast symposium program >>
C 08:30 - 10:00 - CLINICAL TRACK (Sala Cristallo) Sarcopenia & weight loss Chairs:
Tamara Harris, Bethesda, USA
Cornel Sieber, Nuremberg, Germany
Chronobiological considerations regarding the diagnosis, treatment and regulatory evaluation of cachexia & sarcopenia Gerald Sokol, Bethesda, USA
Ultrasound measurement of muscle quality and quantity in sarcopenia and disuse-atrophy Marco Narici, Manchester, UK
Sarcopenia and frailty in the Orient Jean Woo, Hong Kong, China
Managing sarcopenia and cachexia: the telemedicine viewpoint Friedrich Koehler, Berlin, Germany
D 08:30 - 10:00 - BASIC SCIENCE TRACK (Plenary room) Regulation of muscle wasting Chairs:
Alan Russell, Research Triangle Park, USA
David Glass, Cambridge, USA
Molecular control of atrophy in senescent muscle Paul Greenhaff, Nottingham, UK
Nutritional control of muscle atrophy: role of essential amino acids Stephan von Haehling, Berlin, Germany
Muscle wasting and sepsis: Data from the intensive care unit Lars Larsson, Uppsala, Sweden
Role of beta-adrenergic signaling in skeletal muscle structure and function: implications for muscle wasting and disease Gordon Lynch, Melbourne, Australia
Role of micro RNAs Thomas Thum, Hannover, Germany
10:00 - 11:00 - Coffee break & Poster sessions (each presentation: 3 min including discussion)
P 01 Muscle wasting mechanisms I
P 02 Cachexia mechanisms I
P 03 Cancer cachexia I
P 04 Cancer cachexia III
P 05 Therapeutic development (clinical)
P 06 Therapeutic development (pre-clinical) I
E 11:00 - 12:30 - BASIC SCIENCE TRACK (Plenary room) Cancer cachexia Chairs:
Giovanni Mantovani, Monserrato, Cagliari, Italy
Josep Argiles, Barcelona, Spain
Review on animal models for cancer cachexia Jochen Springer, Berlin, Germany
Recent advances in the biology of muscle wasting David Glass, Cambridge, USA
Myostatin as target: 2011 update HQ Han, Thousand Oaks, USA
Follistatin as a target for anabolic therapies Tianshun Xu, Research Triangle Park, USA
Intra-myocellular fat as a determinate of poor functional status Bret Goodpaster, Pittsburgh, USA
F 11:00 - 12:30 - CLINICAL TRACK (Sala Cristallo) From herbal therapy to immune modulation Chairs:
Takashi Higashiguchi, Tsu, Japan
Michael Meguid, Syracuse, USA
Japanese herbal medicine: an overview Akio Inui, Kagoshima, Japan
Cachexia in Vietnam and traditional therapies Kim Anh Hoang, Hochiminh, Vietnam
Immune therapy Hiroaki Nanba, Kobe, Japan
Central mechanisms of lethargy in inflammation and cachexia Daniel Marks, Portland, USA
Muscle phenotype shift and myopenia in stroke Wolfram Doehner, Berlin, Germany
12:45 - 13:45 - INTERACTIVE LUNCHTIME SEMINAR (Sala Cristallo) - Friday 9th December Join the live Sarcopenia debate
Sarcopenia: definition, diagnosis and management
Facilitators:
Maurizio Muscaritoli, Rome, Italy
Tommy Cederholm, Uppsala, Sweden
Lunch will be provided.
Share your views with your peers during this debating session on the definition, screening and treatment of sarcopenia.
This educational activity is organized by The Society on Sarcopenia, Cachexia and Wasting Disorders (SCWD) and supported by an unrestricted educational grant provided by Nutricia. View full details >>
G 14:00 - 15:30 - CLINICAL TRACK (Sala Cristallo) Update on anabolics & related therapies Chairs:
John Morley, St. Louis, USA
Kamyar Kalantar-Zadeh, Torrance, USA
An update on skeletal muscle troponin activators and their potential application in muscle wasting and cachexia Fady Malik, San Francisco, USA
New therapies for cachexia/sarcopenia Ronenn Roubenoff, Boston, USA
Testosterone, sarcopenia and frailty Frederick Wu, Manchester, UK
SARMS Mitch Steiner, Memphis, USA
Ghrelin trial update John Friend, Bridgewater, USA
ACTAs Andrew Coats, Norwich, UK
Panel discussion
H 14:00 - 15:30 - BASIC SCIENCE TRACK (Plenary room) From palliative care to exercise for cachexia Chairs:
Mitja Lainscak, Golnik, Slovenia
Florian Strasser, St. Gallen, Switzerland
Palliative care for cachexia in Japan Takashi Higashiguchi, Tsu, Japan
Palliative care for cancer & cachexia: survival impact Aminah Jatoi, Rochester, USA
Pain and cachexia Yasuhito Uezono, Tokyo, Japan
Integration of exercise in cachexia therapy Ramon Langen, Maastricht, The Netherlands
Failure to thrive and renal cachexia: from pediatrics to geriatrics Robert Mak, La Jolla, USA
15:30 - 16:30 - Coffee break & poster sessions (each presentation: 3 min including discussion)
P 07 Muscle wasting mechanisms II
P 08 Cachexia mechanisms II
P 09 Cancer cachexia II
P 10 Nutrition & Appetite I
P 11 Sarcopenia/Myopenia/Frailty I
I 16:30 - 18:00 - CLINICAL SCIENCE TRACK (Sala Cristallo) Late breaking clinical trials Chairs:
Stefan Anker, Berlin, Germany
Andrew Coats, Norwich, UK
Overview: Regulatory considerations for treatment development in cachexia & sarcopenia Giuseppe Rosano, Rome, Italy
GTx-024, a selective androgen receptor modulator (SARM), improves physical function in non-small cell lung cancer (NSCLC) patients with muscle wasting (8-07); In a Phase IIb trial GTx-024 overcomes the negative impact of >8% weight loss on overall survival in non-small cell lung cancer (NSCLC) subjects (8-08) Shontelle Dodson, Me
Safety and tolerability of LGD-4033, a novel non-steroidal oral Selective Androgen Receptor Modulator (SARM), in healthy men (8-06) Eric Vajda, La Jolla, USA
Randomised phase III clinical trial of a combined treatment with carnitine + celecoxib +/- megestrol acetate for patients with cancer-related anorexia/cachexia syndrome (8-05) Giovanni Mantovani, Monserrato, Cagliari, Italy
Phase I/II trial of formoterol fumarate combined with megestrol acetate in patients with advanced malignancy (8-09) Carolyn Greig, Edinburgh, UK
A phase I study of the effects of a true human, monoclonal antibody against interleukin 1α on lean body mass, nutritional intake and appetite in advanced cancer patients: preliminary findings (8-13) David Hui, Houston, USA
Phase I/II Study of IP-1510 a novel interleukin-1 receptor antagonist in the Management of Cancer-Related Cachexia (8-12) Vasilis Paspaliaris, Melbourne, Australia
Statistical considerations when designing clinical trials for sarcopenia / cachexia Bridget-Anne Kirwan, Nyon, Switzerland
16:30 - 18:15 - JUDGES' CHOICE - BASIC SCIENCE (Plenary room) Chairs:
Josep Argiles, Barcelona, Spain
Thomas Thum, Hannover, Germany
Muscle actin is polyubiquitinated in C2C12 myotubes and human muscle biopsies and targeted for breakdown by the E3 ligase MuRF1 (1-14) Didier Attaix, Clermont-Ferrand, France
The mitochondrial and neuromuscular systems are severely dysregulated in a rat sarcopenia model (5-17) Chikwendu Ibebunjo, Cambridge, USA
Dln101 a naturally occuring ghrelin splice variant for the treatment of cachexia (7-09) Liat Mintz, East Brunswick, USA
Msy-3/Csda coordinates repression of myogenic genes in muscle wasting (1-05) Libera Berghella, Rome, Italy
Common Pathways in Cancer and Cardiac Cachexia (4-08) Michaela Schäfer, Heidelberg, Germany
Tissue-protective effect of the non-hematopoetic erythropoietin analogues ARA284 and ARA286 in the treatment of cancer cachexia (7-20) Yulia Elkina, Berlin, Germany
Leveraging the myostatin signaling pathway with small molecules: inhibitors of the activin receptors’ kinase activity (7-10) Philip Turnbull, Research Triangle Park, USA
Angiotensin II upregulates Pp2cα and inhibits AMPK signaling and energy balance leading to skeletal muscle wasting (2-21) Patrice Delafontaine, New Orleans, USA
Gαi2 signaling promotes skeletal muscle hypertrophy, myoblast differentiation and regeneration via PKC- and HDAC- dependent pathways (1-29) Mara Fornaro, Basel, Switzerland
Total-body creatine pool size and skeletal muscle mass determination by D3-creatine dilution in rats (1-21) Stephen Stimpson, Research Triangle Park, USA
mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass (7-19) Christopher Adams, Iowa City, USA
Pancreatic cancer and ghrelin Chih-Yen Chen, Taipei, Taiwan
20:00 - 22:30 - Cancer Cachexia Awareness Dinner
The SCWD has the pleasure of inviting you to attend its Cancer Cachexia Awareness Dinner at the Museo Diocesano.
Ms. Lisa Niemi Swayze, the wife of Patrick Swayze, will participate in person to share how her life was impacted by the disease.
A professional moderator will facilitate discussions during dinner.
Venue: Museo Diocesano, Corso di Porta Ticinese, 95 - 20123 Milan
Dress code: Cocktail Attire Requested
Dinner fees:
a) for congress participant - 145€
b) for non congress participant - 245€
Pre-booking is highly recommended. Please check at the registration desk for booking.
Day 3 Saturday, 10 December 2011
J 08:00 - 09:30 - YOUNG INVESTIGATORS AWARD SESSION - CLINICAL AND BASIC (Plenary room) Chairs:
John Morley, St. Louis, USA
Maurizio Muscaritoli, Rome, Italy
Additional judges:
Vickie Baracos, Edmonton, Canada
Francesco Dioguardi, Milan, Italy
Wolfram Doehner, Berlin, Germany
Ken Fearon, Edinburgh, UK
Thomas Thum, Hannover, Germany
An investigation of microRNAs in the skeletal muscle of cancer patients with cachexia (3-24) Nathan A. Stephens, Edinburgh, UK
Mechanisms underlying anorexia in adjuvant arthritis: Focus on IL-1beta and orexigenic/anorexigenic neuropeptide mRNA expressions in hypothalamic nuclei (6-03) Andrea Stofkova, Prague, Czech Republic
Low appendicular skeletal mass (ASM) with limited mobility predicts poor outcomes after 6-years in middle-aged African Americans (6-23) Theodore Malmstrom, St. Louis, USA
Central nervous system control of inflammation induced muscle catabolism (1-28) Theodore P. Braun, Portland, USA
Myostatin gene inactivation reduces skeletal muscle mass loss and tumor growth, and increases lifespan in mice with cancer cachexia (4-04) Yann S. Gallot, Lyon, France
MT-102, a new “Anabolic Catabolic Transforming Agent”, reverses effects of sarcopenia in a rat model (7-21) Mareike Pötsch, Berlin, Germany
K 08:00 - 09:30 - NEW SCIENCE (Sala Cristallo) Treatments, mechanisms and new science Chairs:
Denis Guttridge, Columbus, USA
Alessandro Laviano, Rome, Italy
Peptide autoantibodies Serguei Fetissov, Louen, France
IGF-1 update 2011 Volker Adams, Leipzig, Germany
GDF-15 alias MIC-1 and anorexia/cachexia Samuel Breit, Sydney, Australia
Cachexia in acute illness and viruses Carsten Tschöpe, Berlin, Germany
Diabetes and muscle wasting Angela Abbatecola, Ancona, Italy
09:30 - 10:30 - Coffee break & poster sessions
P 12 Cancer cachexia IV
P 13 Muscle wasting mechanisms III
P 14 Sarcopenia/Myopenia/Frailty II
P 15 Nutrition & Appetite II
P 16 Therapeutic development (pre-clinical) II
10:30 - 12:00 - JUDGES' CHOICE (Sala Cristallo)
Oral presentations of selected abstracts
(clinical & nutrition science) Chairs:
Michael Meguid, Syracuse, USA
Stephan von Haehling, Berlin, Germany
Review: Economic cost of sarcopenia and hunger in the United States Donald Shepard, Waltham, USA
Review: COPD cachexia Matthias John, Schwedt, Germany
Association of the surrogate measures of dietary protein intake and survival in 100,088 chronic hemodialysis patients (6-04) Kamyar Kalantar-Zadeh, Torrance, USA
The association of body mass index and presence of cachexia with survival and disability after stroke: data from 1521 hospitalised patients with 30 months follow-up (2-15) Wolfram Doehner, Berlin, Germany
Autonomic nervous system dysfunction in cancer cachexia patients is predominantly sympathetic (4-22) Thomas Hundsberger, St. Gallen, Switzerland
The feasibility and acceptability of neuromuscular electrical stimulation (NMES) in patients with advanced cancer (8-10) Tamara Windholz, Montreal, Canada
Parenteral nutrition in patients with cancer cachexia and bowel obstruction: International survey on indications, outcomes and practices (6-08) Karen Nestor, St. Gallen, Switzerland
L 10:30 - 12:00 - BASIC SCIENCE TRACK (Plenary room) Symptoms / Neuroscience
Neuropeptides and cachexia Herbert Herzog, Sydney, Australia
PTHrP and cachexia Akihiro Asakawa, Kagoshima, Japan
Role of change in neuromuscular junction: Agrin and neurotrypsin in muscle wasting Denis Guttridge, Columbus, USA
Sensor control of cancer cachexia Michael Meguid, Syracuse, USA
Symptoms and symptom generation in cachexia Andrew Coats, Norwich, UK
12:15 - 13:15 - LUNCHTIME SYMPOSIUM - Saturday 10th December (Sala Cristallo) Lunchtime seminar
Challenges to identify endpoints for drug development in wasting diseases
A panel discussion organized by the Society on Sarcopenia, Cachexia and Wasting Disorders (SCWD).
Lunch will be provided.
M 13:30 - 14:45 - PLENARY SESSION (Plenary room) Debates and updates
Pro Belgian Blue Ken Fearon, Edinburgh, UK
Pro Kobe Beef John Morley, St. Louis, USA
Nutrition and inflammation Filippo Rossi-Fanelli, Rome, Italy
Cachexia and cardio-renal-anemia syndrome Kamyar Kalantar-Zadeh, Los Angeles, USA
Highlights from our journal: editor’s choice Stephan von Haehling, Berlin, Germany
14:45 - 15:15 - Coffee break
N 15:15 - 16:30 - PLENARY SESSION (Plenary room) Congress highlights Chairs:
Giuseppe Rosano, Rome, Italy
Filippo Rossi-Fanelli, Rome, Italy
Akio Inui, Kagoshima, Japan
John Morley, St. Louis, USA
Basic Science Denis Guttridge, USA
Sarcopenia William Evans, Research Triangle Park, USA
Nutritional Therapies Maurizio Muscaritoli, Rome, Italy
Treatment of cachexia Stefan Anker, Berlin, Germany
AWARDS CEREMONY
Poster Award
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Full Program,
